Spurs had very few managers in the years up to 1975, but since, then there has been a constant turnover of men on the hot seat.
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| Frank BRETTELL | February 1898 – February 1899 |
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| John CAMERON (Player-Manager) | February 1899 – March 1907 |
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| Fred KIRKHAM | 22 April 1907 – 1908 |
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| Arthur TURNER | 1908 – 1912 |
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| Peter McWILLIAM | 21 December 1912 – 1927 |
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| Billy MINTER | 28 February 1927 – 20 November 1929 |
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| Percy SMITH | November 1929 – April 1935 |
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| Wally HARDINGE (Caretaker) | 1935 |
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| Jack TRESADERN | June 1935 – April 1938 |
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| Peter McWILLIAM | 1938 – 1942 |
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| Arthur TURNER | August 1942 – 1946 |
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| Joe HULME | 1946 – 1949 |
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| Arthur ROWE | 1949 – 18 April 1955 |
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| Jimmy ANDERSON | 18 April 1955 – 11 October 1958 |
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| Bill NICHOLSON | 11 October 1958 – September 1974 |
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| Terry NEILL | September 1974 – 9 July 1976 |
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| Keith BURKINSHAW | 14 July 1976 – 31 May 1984 |
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| Peter SHREEVE | 1984 – March 1986 |
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| David PLEAT | May 1986 – October 1987 |
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| Terry VENABLES | 23 November 1987 – June 1991 |
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| Peter SHREEVE | July 1991 – May 1992 |
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| Doug LIVERMORE / Ray CLEMENCE | 1992 – 1993 |
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| Osvaldo ARDILES | 1993 – October 1994 |
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| Steve PERRYMAN (Caretaker) | 1994 |
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| Gerry FRANCIS | 1994 – November 1997 |
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| Chris HUGHTON (Caretaker) | November 1997 |
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| Christian GROSS | 19 November 1997 – 5 September 1998 |
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| David PLEAT (Caretaker) | September 1998 – October 1998 |
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| George GRAHAM | October 1998 – March 2001 |
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| David PLEAT (Caretaker) | March 2001 |
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| Glenn HODDLE | April 2001 – September 2003 |
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| David PLEAT (Caretaker) | September 2003 – May 2004 |
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| Jacques SANTINI (Head Coach) | July 2004 – 6 November 2004 |
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| Martin JOL (Head Coach) | 6 November 2004 – 25 October 2007 |
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| Clive ALLEN / Alex INGLETHORPE (Caretaker) | 25 October 2007 – 29 October 2007 |
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| Juande RAMOS (Head Coach) | 29 October 2007 – 25 October 2008 |
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| Clive ALLEN / Alex INGLETHORPE (Caretaker) | 26 October 2008 |
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| Harry REDKNAPP | 26 October 2008 – 14 June 2012 |
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| Andre VILLAS-BOAS (Head Coach) | 3 July 2012 – 16 December 2013 |
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| Tim SHERWOOD (Head Coach) | 16 December 2013 – 13 May 2014 |
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| Mauricio POCHETTINO | 28 May 2014 – 19 November 2019 |
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| Jose MOURINHO | 20 November 2019 – 19 April 2021 |
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| Ryan MASON (Interim Manager) | 20 April 2021 – May 2021 |
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| Nuno ESPIRITO SANTO (Head Coach) | 30 June 2021 – 1 November 2021 |
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| Antonio CONTE (Head Coach) | 2 November 2021 – 26 March 2023 |
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| Cristian STELLINI (Acting Head Coach) | 26 March 2023 – 24 April 2023 |
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| Ryan MASON (Acting Head Coach) | 24 April 2023 – 5 June 2023 |
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| Ange POSTECOGLOU (Head Coach) | 6 June 2023 – 6 June 2025 |
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| Thomas FRANK (Head Coach) | 12 June 2025-??? |
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| ??? | 20?? |
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